This article reviews the pathophysiology of salicylate metabolism, the clinical and diagnostic clues of an acute overdose, and the cellular response of salicylate poisoning on various organ systems, as well as differential diagnoses and treatment approaches to toxicity in children. Despite a decline in popularity, this chemical compound’s ubiquity and accessibility results in it being frequently implicated in childhood drug poisonings. If you suspect your dog or cat were poisoned by aspirin, call your veterinarian or Pet Poison Helpline® immediately for life-saving treatment recommendations.Abstract: Salicylate and its derivatives are commonly found worldwide in common medications used to treat pain, fever, and inflammation. Aggressive treatment is necessary with toxic amounts, and includes decontamination, gastrointestinal protectants, symptomatic and supportive care, IV fluids, and blood work monitoring. Signs of aspirin poisoning in dogs or cats include gastrointestinal signs (e.g., vomiting, diarrhea, vomiting of blood, black-tarry stool, stomach ulcers, etc.), hyperthermia, respiratory changes, bone marrow suppression, kidney failure, and central nervous system signs (e.g., collapse, extreme weakness, tremors, seizures, cerebral edema). Sources of aspirin include Pepto-Bismol®, topical medications (e.g., shampoos, medications for acne, warts, calluses, etc.), make-up (e.g., foundations and concealers), liniments (e.g., Bengay®, HEET®, Icy Hot, etc.), and oil of wintergreen.Ĭats are much more sensitive to aspirin poisoning than dogs.
However, when aspirin (or its similar salicylate-containing compounds) are inappropriately ingested, it can result in severe poisoning in dogs and cats. When used at appropriate doses in pets, aspirin is used for pain management for osteoarthritis to clot prevention. Aspirin (also known as acetylsalicylic acid or ASA) is a common over-the-counter (OTC) non-steroidal anti-inflammatory (NSAID) used in both human and veterinary medicine.
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